Synthesis and pharmacology of benzodiazepine derivatives

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The pyrrole derivatives having carbonyl groups at the C-2 position were converted to N-propargyl pyrroles. The reaction of those compounds with hydrazine monohydrate resulted in the formation of 5H-pyrrolo[2,1-d][1,2,5]triazepine derivatives. The synthesis of these compounds was accomplished in three steps starting fr…

• NURETTİN MENGEŞ

Benzoxazines with amide linkages were successfully prepared from 3,4-dihydrocoumarine using either one-pot or stepwise pathways.

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• GONCAGÜL SERDAROĞLU

A series of benzimidazolium salts having 2‐cyanobenzyl ( 2 – 6 ), 2‐(4‐nitrophenyl)ethyl ( 7 – 10 ), (1,3‐dioxoisoindolin‐2‐yl)butyl ( 11 – 17 ) or N ‐methylphthalimide ( 18 – 22 ) substitution were synthesized and characterized by spectroscopic and analytical techniques. The in vitro cytotoxic activity of these salts…

• SENEM AKKOÇ

A series of new 2-aryl-3-[(2-furyl)carbonyl]amino-5-nonsubstituted/methyl-4-thi azolidinones (3) and 2-[(2-furyl)carbonyl]hydrazono-3-alkyl-4-aryl-4-thiazolines (5) was synthesized and evaluated for anticonvulsant activity against pentylenetetrazole induced seizures. Preliminary results indicated that potency was sens…

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated for in vitro cytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that 23, 26 and 29 exhibit bette…

• NİZAMİ DURAN

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated for in vitro cytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that 23, 26 and 29 exhibit bette…

• MEHMET ABDULLAH ALAGÖZ
• NİZAMİ DURAN

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated for in vitro cytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that 23, 26 and 29 exhibit bette…

• ÖZTEKİN ALGÜL

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated for in vitro cytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that 23, 26 and 29 exhibit bette…

• SERDAR BURMAOĞLU

Abstract An estimated 50 million people suffer epilepsy worldwide and 30% of the cases do not respond to current antiepileptic drugs (AEDs). Here, we report synthesis and anticonvulsant screening of new derivatives of nafimidone, a well‐known member of (arylakyl)azole anticonvulsants. The compounds showed promising pr…

• SUAT SARI

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• ESRA EMERCE