FOXO transcription factor regulation

The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive, migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to generate metastases. Inducers of the EMT include several transcription factors (TFs), such as Goosecoid, Snail, and Twist, as well as t…

• TEVFİK TAMER ÖNDER

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• AYŞEGÜL ERDEMİR

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Glioblastoma multiforme (GBM) is a life-threatening brain tumor. Accumulating evidence suggests that eradication of glioma stem-like cells (GSCs) in GBM is essential to achieve cure. The transcription factor FOXM1 has recently gained attention as a master regulator of mitotic progression of cancer cells in various org…

• CENK KIĞ

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• FATİH KOCABAŞ

Steroid receptor coactivator (SRC)-3, also called amplified in breast cancer 1, is a member of the p160 nuclear receptor coactivator family involved in transcriptional regulation of target genes. SRC-3 is frequently amplified and/or overexpressed in hormone-sensitive and hormone-insensitive tumors. We reported previou…

• MUSTAFA ÖZEN

// Zuhal Hamurcu 1, 2, 3 , Ahmed Ashour 1 , Nermin Kahraman 1 , Bulent Ozpolat 1, 4 1 Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Faculty of Medicine, Department of Medical Biology, Erciyes University, Kayseri, Turkey 3 Betül-Ziya Eren Genome and St…

• ZÜHAL HAMURCU

BACKGROUND: Proteins of the insulin signaling pathway are needed for cell proliferation and development and glucose homeostasis. It is not known whether insulin signalling markers (Foxo1, Gsk3β) can be correlated with the expression on PI3K-Akt-mTOR pathway, which are needed for cell survival and maintenance of glucos…

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• NAZMİ VOLKAN ADSAY

Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest human cancers, with 1-5% 5-year survival rates (~6-month median survival duration) despite therapy; thus, PDAC represents an unmet therapeutic challenge. PDAC is the major histological subtype, comprising 90% of all pancreatic cancers. It is a…

• GÜLİNNAZ ERCAN