Protein Tyrosine Phosphatases

No abstract yet.

No abstract yet.

• ZİHNİ AÇAR YAZICI

No abstract yet.

Druggability assessment of a target protein has emerged in recent years as an important concept in hit-to-lead optimization. A reliable and physically relevant measure of druggability would allow informed decisions on the risk of investing in a particular target. Here, we define "druggability" as a quantitative estima…

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTα-Haloacetophenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine PhosphatasesGulnur Arabaci, Xiao-Chuan Guo, Kirk D. Beebe, K. Mark Coggeshall, and Dehua PeiView Author Information Departments of Chemistry and Microbiology Ohio State Biochemist…

• GÜLNUR ARABACI

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTα-Haloacetophenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine PhosphatasesGulnur Arabaci, Xiao-Chuan Guo, Kirk D. Beebe, K. Mark Coggeshall, and Dehua PeiView Author Information Departments of Chemistry and Microbiology Ohio State Biochemist…

The accumulation of oxygen in the atmosphere created an evolutionary stress for organisms to survive because oxygen, while the by-product of photosynthesis and an important substrate in oxidative metabolism, can also be partially reduced to form toxic products. These forms of oxygen, reduced by one electron or two ele…

• MUTAY AYDIN ASLAN

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci of weak effect act additively to predispose to common autoimmune diseases, while the contribution of rare variants remains unclear. Here we describe that rare coding variants in lupus-risk…

• MEHMET YABAŞ

No abstract yet.

• TUNÇ AKKOÇ

The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2). The expression of SHP2 is necessary for BCR-ABL-dependent oncogenic transformation, but the precise signaling mech…

• EMEL BAŞAK GENCER AKÇOK

Cardio-facio-cutaneous (CFC) and Costello syndrome (CS) are congenital disorders with a significant clinical overlap. The recent discovery of heterozygous mutations in genes encoding components of the RAS-RAF-MAPK pathway in both CFC and CS suggested a similar underlying pathogenesis of these two disorders. While CFC…

• BEYHAN TÜYSÜZ

Dephosphorylation of the inhibitory "S259" site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS oncoproteins, interacts with SHOC2 and protein phosphatase 1 (PP1) to form a heterotrimeric holoenzyme that dephosphorylates this S259 RAF site. MRAS…

• SİBEL SARI TÜRK