Mast cells and histamine

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas also frequently ex…

• NEŞE DEMİRKAN

Urticaria is a common disease in children. In contrast to the ease of its diagnosis, etiologic factors are often difficult to determine. In order to study whether differences exist among various forms of urticaria in childhood and whether the patterns of different types of urticaria differ between adults and children,…

• BÜLENT ENİS ŞEKEREL

AIMS: Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have been recorded tha…

• LEVENT DERTSİZ

The activation of innate immune cells triggers numerous intracellular signaling pathways, which require tight control to mount an adequate immune response. The PI3K signaling pathway is intricately involved in innate immunity, and its activation dampens the expression and release of proinflammatory cytokines in myeloi…

Myeloid leukemia arises from leukemia stem cells (LSCs), which are resistant to standard chemotherapy agents and likely to be a major cause of drug-resistant disease and relapse. To investigate the in vivo properties of LSCs, we developed a mouse model in which the biologic features of human LSCs are closely mimicked.…

• SELÇUK SÖZER TOKDEMİR

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• VAHİDE BAYSAL AKKAYA

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• EMİNE NİHAL METE GÖKMEN

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• HELEN SHERIDAN KELLEHER

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• ANDAÇ SALMAN

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• ASLI AKKOR

PURPOSE: This study aimed to investigate the autoimmune basis of idiopathic granulomatous mastitis (IGM) by determining the anti-nuclear antibody (ANA) and extractable nuclear antigen (ENA) levels of patients diagnosed with IGM. MATERIAL AND METHODS: Twenty-six IGM patients were evaluated. Serum samples were analyzed…

• İHSAN HAKKI ÇİFTCİ

PURPOSE: This study aimed to investigate the autoimmune basis of idiopathic granulomatous mastitis (IGM) by determining the anti-nuclear antibody (ANA) and extractable nuclear antigen (ENA) levels of patients diagnosed with IGM. MATERIAL AND METHODS: Twenty-six IGM patients were evaluated. Serum samples were analyzed…

• FATİH ALTINTOPRAK