DNA and Nucleic Acid Chemistry

The relationship between dNTP levels and DNA synthesis was investigated using alpha factor-synchronized yeast treated with the ribonucleotide reductase inhibitor hydroxyurea (HU). Although HU blocked DNA synthesis and prevented the dNTP pool expansion that normally occurs at G1/S, it did not exhaust the levels of any…

• AHMET KOÇ

We have found that the efficiency of fluorescence resonance energy transfer between Cy3 and Cy5 terminally attached to the 5' ends of a DNA duplex is significantly affected by the relative orientation of the two fluorophores. The cyanine fluorophores are predominantly stacked on the ends of the helix in the manner of…

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• KADRİYE ARZUM ERDEM GÜRSAN

DNA with tandem repeats of guanines folds into G-quadruplexes made of a stack of G-quartets. In vitro, G-quadruplex formation inhibits telomere extension, and POT1 binding to the single-stranded telomeric DNA enhances telomerase activity by disrupting the G-quadruplex structure, highlighting the potential importance o…

The world of drug designing is ever changing. The investigations of drug-DNA interactions would provide new compounds to be tested for an effect on a biochemical target, and also to be used as promising hybridization indicators for the design of DNA biosensors, which will further become DNA microchip systems. An overv…

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of Zwitterionic Shell Cross-Linked MicellesV. Bütün, A. B. Lowe, N. C. Billingham, and S. P. ArmesView Author Information School of Chemistry, Physics and Environmental Science University of Sussex, Falmer, Brighton, BN1 9QJ, UK Cite this: J. Am. Chem. Soc. 1…

• VURAL BÜTÜN

SUMMARY: Molecular dynamics (MD) determines the physical motions of atoms of a biological macromolecule in a cell-like environment and is an important method in structural bioinformatics. Traditionally, measurements such as root mean square deviation, root mean square fluctuation, radius of gyration, and various energ…

• CANAN ATILGAN

SUMMARY: Molecular dynamics (MD) determines the physical motions of atoms of a biological macromolecule in a cell-like environment and is an important method in structural bioinformatics. Traditionally, measurements such as root mean square deviation, root mean square fluctuation, radius of gyration, and various energ…

• ALİ RANA ATILGAN

Magnetic bead capture has been used for eliminating non-specific adsorption effects hampering label-free detection of DNA hybridization based on stripping potentiometric measurements of the target guanine at graphite electrodes. In particular, the efficient magnetic separation has been extremely useful for discriminat…

• KADRİYE ARZUM ERDEM GÜRSAN

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• ALİ RANA ATILGAN

The interaction of double stranded DNA (dsDNA) and single stranded DNA (ssDNA) with Ru(II) complex with 2,2′-bipyridine ligand (Ru(bpy)3]2+) and methylene blue (MB) were explored by using voltammetric and spectrophotometric methods. The electrochemistry of [Ru(bpy)3]2+ and MB was also investigated at a dsDNA-modified…

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