Lipid Membrane Structure and Behavior

SNAREs (soluble NSF-attachment protein receptors) are generally acknowledged as central components of membrane fusion reactions, but their precise function has remained enigmatic. Competing hypotheses suggest roles for SNAREs in mediating the specificity of fusion, catalyzing fusion, or actually executing fusion. We g…

• MEHMET YILDIRIM SARA

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNormal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane ProteinsIvet Bahar*, Timothy R. Lezon†, Ahmet Bakan†, and Indira H. ShrivastavaView Author Information Department of Computational Biology, School of Medicine, University of Pittsburgh, 3064 BS…

No abstract yet.

• FERİDE SEVERCAN

Cholesterol and sphingomyelin form together a highly ordered membrane phase, which is believed to play important biological functions in plasma membranes of mammalian cells. Since sphingomyelin is present mainly at the outer leaflet of cell membranes, monitoring its lipid order requires molecular probes capable to bin…

• ŞULE ÖNCÜL

No abstract yet.

• MEHMET YILDIRIM SARA

Polyacrylamide hydrogels formed via hydrophobic interactions between stearyl groups in aqueous micellar solution of sodium dodecyl sulfate (SDS) present two faces depending on which state they are. The gels containing SDS micelles exhibit, in addition to the fast mode, a slow relaxation mode in dynamic light scatterin…

• DENİZ CEYLAN

No abstract yet.

• AMIRHOUSHANG BAHRAMI

To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the specific delivery of drug molecules to the subcellular site of action. We show here that surface modification of nanocarriers with mitochondriotropic triphenylpho…

• SUNA ERDOĞAN

Membrane fusion in eukaryotic cells is thought to be mediated by a highly conserved family of proteins called SNAREs (soluble N-ethyl maleimide sensitive-factor attachment protein receptors). The vesicle-associated v-SNARE engages with its partner t-SNAREs on the target membrane to form a coiled coil that bridges two…

The endosomal sorting complexes required for transport (ESCRTs) catalyze reverse-topology scission from the inner face of membrane necks in HIV budding, multivesicular endosome biogenesis, cytokinesis, and other pathways. We encapsulated ESCRT-III subunits Snf7, Vps24, and Vps2 and the AAA+ ATPase (adenosine triphosph…

• AMIRHOUSHANG BAHRAMI

In the last 20 years, an increasing number of studies have been reported on membrane active peptides. These peptides exert their biological activity by interacting with the cell membrane, either to disrupt it and lead to cell lysis or to translocate through it to deliver cargos into the cell and reach their target. Me…

• BERNA SARIYAR AKBULUT
• FATMA GİZEM AVCI

Membrane fusion in exocytosis, intracellular trafficking, and enveloped viral infection is thought to be mediated by specialized proteins acting to merge membrane lipid bilayers. We now show that one class of naturally-occurring phospholipids, lysolipids, inhibits fusion between cell membranes, organelles, and between…