Catalytic C–H Functionalization Methods

In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituent and the nature of…

• ŞARON ÇATAK

Direct functionalization of sp 2 C−H bonds via ortho diarylation of 2-pyridyl benzene with arylbromides was achieved using ruthenium(II) catalysts containing a RuCl 2 (NHC) unit and generated from [RuCl 2 (arene)] 2 and two types of NHC precursors, pyrimidinium and benzimidazolium salts, in the presence of Cs 2 CO 3 .…

• SERPİL DEMİR DÜŞÜNCELİ

Single-electron-mediated alkyl transfer affords a novel mechanism for transmetalation, enabling cross-coupling under mild conditions. Here, general conditions are reported for cross-coupling of secondary alkyltrifluoroborates with an array of aryl bromides mediated by an Ir photoredox catalyst and a Ni cross-coupling…

• İDRİS KARAKAYA

Certain Cu(I) and Cu(II) salts are able to mediate the dimerization of arylboronic acids in DMF. They provide the corresponding symmetrical biaryls in moderate to very good yields. It is possible to run the reaction catalytically under an oxygen atmosphere without a significant loss of yields.

Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of Csp(3) hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox cataly…

• İDRİS KARAKAYA

A variety of neutral ruthenium−carbene complexes RuCl 2 (carbene)(arene) 1 (carbene = C(NR)C 6 H 4 (NR), R = Me ( a ), Et ( b ); arene = p -Me-C 6 H 4 - i Pr ( 1 ), C 6 H 3 Me 3 ( 2 ), C 6 Me 6 ( 3 )) have been prepared by reaction of [RuCl 2 (arene)] 2 precursors with the enetetraamines (RN)C 6 H 4 (RN)C C(NR)C 6 H 4…

• HASAN KÜÇÜKBAY

Synthesis of pyrazoles via electrophilic cyclization of α,β-alkynic hydrazones by copper(I) iodide is described. When treated with copper(I) iodide in the presence of triethylamine in refluxing acetonitrile, α,β-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electroph…

• METİN ZORA

Synthesis of pyrazoles via electrophilic cyclization of α,β-alkynic hydrazones by copper(I) iodide is described. When treated with copper(I) iodide in the presence of triethylamine in refluxing acetonitrile, α,β-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electroph…

• ARİF KIVRAK

Free radical reactions have become increasingly important, as well as a very attractive tool, in organic synthesis within the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Mn(OAc)3 mediated oxidative free radical reactions have been extensively developed in the last twenty…

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• LEVENT ARTOK

Proline-thiourea host-guest complex-catalyzed direct enantioselective aldol reactions have been developed, in which the catalytic activities were evaluated in the direct asymmetric aldol reactions of various aromatic aldehydes and cyclohexanone.

• SERKAN EYMUR

The applications of nitroalkenes in the synthesis of small, common and medium ring carbocycles, including natural products are investigated in this review. These carbocyclic compounds were synthesized from cyclic or acyclic nitroalkenes via a wide variety of reactions such as Michael addition, Diels–Alder reaction, 1,…

• AZİM ZİYAEİ HALİMEHJANİ