Article detail · 2020 · article
Dual stimuli-responsive chitosan grafted poly(NIPAM-co-AAc)/poly(vinyl alcohol) hydrogels for drug delivery applications
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- YÖKSİSYÖKSİS article record
- YÖKSİS venueInternational Journal of Polymeric Materials and Polymeric Biomaterials
- Catalog match (ISSN)International Journal of Polymeric Materials and Polymeric Biomaterials
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Abstract
Herein, we synthesized poly(vinyl alcohol) (PVA) decorated chitosan grafted poly(NIPAM-co-AAc) hydrogels through free-radical copolymerization. Increased PVA concentration revealed enhancement of temperature and pH sensitivity of the hydrogel by changing the porous structure and surface properties. Further, in vitro drug delivery studies carried out with a model dye revealed a six-fold increased release of the content at pH 7.4 with respect to pH 4.4. This new combination of three component hydrogels could be effectively used as an alternative material in the development of stimuli triggered drug delivery systems that are stable at tissues and organs with a low pH environment.
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Citations
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23citationsOpenAlex · cited_by_count (cache / database)
7 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- 2023 Investigation of use in 5-FU release: Synthesis of temperature and pH responsive P(NVCL-co-VIm)/PVP hydrogelsCitations 6 · OpenAlex
- 2023 Investigation of use in 5-FU release: Synthesis of temperature and pH responsive P(NVCL-co-VIm)/PVP hydrogelsCitations 6 · OpenAlex
- 2023 A bi-layer electrospun polyurethane/silicone membrane scaffold: drug delivery and cytotoxicity studiesCitations 4 · OpenAlex
- 2023 A bi-layer electrospun polyurethane/silicone membrane scaffold: drug delivery and cytotoxicity studiesCitations 4 · OpenAlex
- 2024 Chitosan based injectable cryospheres as a potential biopolymeric carrier for drug delivery systems: Characterization, biocompatibility and drug releaseCitations 2 · OpenAlex
- 2024 Chitosan based injectable cryospheres as a potential biopolymeric carrier for drug delivery systems: Characterization, biocompatibility and drug releaseCitations 2 · OpenAlex
- 2024 Chitosan based injectable cryospheres as a potential biopolymeric carrier for drug delivery systems: Characterization, biocompatibility and drug releaseCitations 2 · OpenAlex