melanin and skin pigmentation

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• IŞIL KURNAZ

The significance of melanotropic hormones as physiologic regulators of cutaneous pigmentation in humans is still controversial. Until recently, no direct effect for melanotropins could be demonstrated on human melanocytes. Here we present conclusive evidence that alpha-melanotropin (alpha-melanocyte-stimulating hormon…

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas also frequently ex…

• NEŞE DEMİRKAN

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• NEŞET CEVDET TOLGA EMRE

The development of melanocytes, which are pigment-producing cells responsible for skin, hair, and eye color, is absolutely dependent on the action of the microphthalmia basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor (Mi); mice lacking a functional Mi protein are entirely devoid of pigment cells.…

• IŞIL KURNAZ

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BACKGROUND: Vitiligo is a common skin disease characterized by autoimmune melanocyte destruction. Recent genetic studies suggest a lower susceptibility to melanoma in patients with vitiligo; however, lifetime melanoma prevalence in patients with vitiligo has not previously been studied. Nonmelanoma skin cancer (NMSC)…

The electrochemical and photoelectrochemical detection of tyrosinase (TR) activity (an indicative marker for melanoma cancer cells) is reported, using Pt nanoparticles (NPs) or CdS NPs as electrocatalytic labels or photoelectrochemical reporter units. The Pt NPs or CdS NPs are modified with a tyrosine methyl ester, (1…

• HÜSEYİN BEKİR YILDIZ

A novel thresholding-based segmentation approach for accurate segmentation of pigmented skin lesion images regarding malignant melanoma diagnosis has been proposed. The presented approach utilizes type-2 fuzzy logic techniques for automatic threshold determination. The method is applied on various clinically obtained…

• MURAT BORLU

A novel thresholding-based segmentation approach for accurate segmentation of pigmented skin lesion images regarding malignant melanoma diagnosis has been proposed. The presented approach utilizes type-2 fuzzy logic techniques for automatic threshold determination. The method is applied on various clinically obtained…

• MEHMET EMİN YÜKSEL

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• MUSTAFA METİN DONMA