Alteration of Paraoxonase, Ceruloplasmin and Immunoglobulin G levels in Hair Goats at Different Ages

OpenAlex İngilizce

In this study, the alteration of paraoxonase, ceruloplasmin and immunoglobulin G levels in hair goats at different ages were investigated. 88 hair goats grazed in the same season in Adana (Turkey) were included in the study. Goats were divided into five groups as 0-6 months old, 7-12 months old, 1.5-2 years old, 2.5-6 years old and 7< years old. Paraoxonase activity and ceruloplasmin levels were measured by spectrophotometer and immunoglobulin G was measured with ELISA kit. Although there was no statistically significant difference between the groups in paraoxonase activity, it increased until 6 years of age, but decreased with aging. A statistically significant difference was found between the groups in ceruloplasmin levels. While it provided a decrease in values up to the age of 2 and in old age, a little increase was observed in the fourth group. A statistically significant difference was found between the groups in immunoglobulin G levels, and it was observed that immunoglobulin G levels increased from newborns to adulthood, decreased with age, but increased again with aging. As a result, aging actually means an increase in reactive oxygen species, the emergence of diseases, and the loss of function of tissues and cells. Based on this, it can be said that as you get older, the body will become open to microorganisms and the emergence of diseases will increase. These results suggest that immunoglobulin G increase with age to protect the body. Paraoxonase and ceruloplasmin levels also showed significant change with age. However, more extensive studies are needed to reveal the cause more precisely.