Makale detayı · 2010 · article
Effects of drugs on kinetic values of cytokines, adenosine deaminase and 13,14-dihydro-15-keto-prostaglandin F2α in endotoxemia: a different approach.
Veri kaynağı ayrımı
- YÖKSİS dergi adıDergiPark (Istanbul University)
- OpenAlexOpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
Gerec ve Yontem: Arastirmada kullanilan ratlar 7 gruba ayrildi. Deneysel endotoksemi olusturmak icin pozitif kontrol grubu dahil butun gruplara LPS uygulandi. Diger alti gruba ENR, FM, dusuk doz DEX, yuksek doz DEX, ENR+FM+dusuk doz DEX ve ENR+FM+yuksek doz DEX uygulandi. Uygulama sonrasi 0, 1, 2, 4, 6, 8, 12, 24 ve 48. saatlerde kan ornekleri toplandi. Tumor nekroz faktor alfa (TNFα), interlokin-6 (IL6), interlokin-10 (IL-10), ADA ve PGM duzeyleri ELISA ile belirlendi. Egri altinda kalan alan (EAA0-48) farmakokinetik programla, plazma veya serum maksimum konsantrasyon (Cmax) ile maksimum konsantrasyona ulasma zamani (tmax) direk baki yontemiyle belirlendi.
Konular
Atıflar
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